Search results for "Immune priming"
showing 7 items of 7 documents
Relationship between maternal transfer of immunity and mother fecundity in an insect.
2012
Trans-generational immune priming (TGIP) corresponds to the plastic adjustment of offspring immunity as a result of maternal immune experience. TGIP is expected to improve mother's fitness by improving offspring individual performance in an environment where parasitism becomes more prevalent. However, it was recently demonstrated that maternal transfer of immunity to the offspring is costly for immune-challenged female insects. Thus, these females might not provide immune protection to all their offspring because of the inherent cost of other fitness-related traits. Females are therefore expected to adjust their investment to individual offspring immune protection in ways that maximize the…
Lepidopteran species have a variety of defence strategies against bacterial infections
2017
The insect immune system has versatile ways of coping with microbial insults. Currently, innate immune priming has been described in several invertebrates, and the first insights into its mechanistic basis have been described. Here we studied infections with two different strains of Serratia marcescens bacteria in two different Lepidopteran hosts. The results reveal fundamental differences between the two hosts, a well-known model organism Galleria mellonella and a non-model species Arctia plantaginis. They differ in their strategies for resisting oral infections; priming their defences against a recurring sepsis; and upregulating immunity related genes as a response to the specific pathoge…
Insect immunity: oral exposure to a bacterial pathogen elicits free radical response and protects from a recurring infection
2014
Background: Previous exposure to a pathogen can help organisms cope with recurring infection. This is widely recognised in vertebrates, but increasing occasions are also being reported in invertebrates where this phenomenon is referred to as immune priming. However, the mechanisms that allow acquired pathogen resistance in insects remain largely unknown. Results: We studied the priming of bacterial resi stance in the larvae of the tiger moth, Parasemia plantaginis using two gram-negative bacteria, a pathogenic Serratia marcescens and a non-pathogenic control, Escherichia coli. Asublethaloraldoseof S. marcescens provided the larvae with effective protection against an otherwise lethal septic…
Immunological priming in the wood tiger moth (Parasemia plantaginis)
2014
Hyönteisiin lukeutuu monia merkittäviä tuholaisia, taudinvälittäjiä ja hyödyllisiä lajeja, minkä takia hyönteisten taudit, taudinaiheuttajat ja immuunipuolustus ovat ekologisesta, ekonomisesta ja lääketieteellisestä näkökulmasta tärkeitä tutkimuskohteita. Viimeaikaiset tutkimukset paljastavat hyönteisten ja muiden selkärangattomien immuunijärjestelmien pystyvän erikoistumaan ja luomaan pitkäkestoista immuniteettia. Jälkimmäinen ilmiö tunnetaan tieteellisissä artikkeleissa nimellä ”immunological priming”, jonka voisi kääntää suomeksi esimerkiksi ”immuunipohjustukseksi”. Immuunipohjustus on muistinkaltaista vastustuskykyä, joka auttaa elimistöä puolustautumaan tehokkaammin toistuvia tartuntoj…
Evolutionary ecology of immune priming in the mealworm beetle, Tenebrio molitor
2017
Many organisms can improve their immune response as a function of their immunological experience, a phenomenon called immune priming. While the mechanisms through which immune priming is achieved remain unknown, individuals that survived to a given parasite are better protected against subsequent exposures. This immune priming can cross generations (trans-generational immune priming – TGIP), preparing offspring for prevailing parasite environment. Both individual and trans-generational immune priming might be adaptive and may have evolved from repeated challenges by the same pathogens during the host lifetime or across generation. While protection could be cross-reactive, a certain level of…
Evolutionary ecology of the trans-generational immune priming in an insect
2012
Trans-generational immune priming (TGIP) is defined as the plastic enhancement of offspring's immunocompetence following an immune challenge of the females of the parental generation. In vertebrates, this phenomenon is well described, and is achieved by the maternal transfer of antibodies. In invertebrates however, it has only recently been described. Since invertebrates do not possess antibodies, the mechanism of this transmission remains unknown. If the offspring is exposed to the maternal infection, an elevated immunocompetence can help it cope better with it. Nonetheless, apart from this benefit, several cues indicate that the TGIP bears some fitness costs for individuals. The evolution…